5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies

By Ning Zhang, Ying Yin, Sheng-Jie Xu, Wei-shan Chen. Molecules, 2008

734 citations recorded by the source corpus.

The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involved in resistance with microarray techniques. The details of the induction and reversal of the drug resistance are also described.

Subfields: Biotechnology, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/357e42f8a2eee4c7fa450c02b5157bc34fbd96ee

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1. S. Heerboth
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3. Mckenna Longacre
4. Shannon Byler
5. K. Lapinska
6. S. Sarkar
7. N. Snyder

Citations in the corpus

• Drug Resistance in Cancer: An Overview (2014, background): “This TS-FdUMP-CH2THF complex results in a slowly reversible inactivation of the enzyme [24].”