Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

By S. Joseph, A. Castrillo, B. Laffitte, D. Mangelsdorf, P. Tontonoz. Nature Medicine, 2003

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Apoptotic cells promote their own clearance and immune tolerance through activation of LXR (2009, positive): “Pharmaco- logically activated LXRs have also been shown to transrepress inflammatory gene expression (Castrillo et al., 2003a; Ghisletti et al., 2007; Joseph et al., 2003).”
Liver X receptor signaling pathways in cardiovascular disease. (2003, background): “Recently, LXR agonists were shown to antagonize the expression of a battery of inflammatory genes in activated macrophages (69).”
LXR signaling couples sterol metabolism to proliferation in the acquired immune response (2008, background): “in the Acquired Immune Response”
Inflammatory Mechanisms in the Regulation of Insulin Resistance (2008, neutral): “TNF-α (5,6) Adiponectin (33,36,42) NF-κB/IKKβ (74,77,78) Osteopontin (104) IL-1α/β (12,14) Leptin (48-50) JNK-1 (79,80) SAA (127) Gp130 family (IL-6, CNTF) (18,19,24) Resistin (55,56,59) PPARγ (84,86) CRP (96,99,101) IL-10 (128,129) PBEF/nampt/visfatin (61-64) SREBP-1c (92-95) FABP-4 (102,103) IL-18”