A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells
By H. Niwa, Kazuya Ogawa, Daisuke Shimosato, Kenjiro Adachi. Nature, 2009
884 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6dc229101ae0408e707dc8a78cb203c833fa711e
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In Molecular Biology
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Citations in the corpus
- Control of Embryonic Stem Cell State (2011, neutral): “, 2006); 11 (Han et al.; Ivanova et al., 2006; Niwa et al., 2009), 12 (Galan-Caridad et al.”
- Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination (2016, background): “With respect to the inhibition of GSK3 signalling, several reports have shown that PI3K signalling inhibits GSK3α/β activity by phosphorylating the S21/S9 residue via AKT activation in mESCs, which leads to the upregulation of pluripotent transcription factors TBX3 and NANOG that subsequently promot”
- The Transcriptional and Epigenomic Foundations of Ground State Pluripotency (2012, background): “When taken together with the observation that several pluripotency factors are expressed heterogeneously (Chambers et al., 2007; Niwa et al., 2009; Toyooka et al., 2008), the notion has arisen that pluripotency may inherently be a metastable condition (Graf and Stadtfeld, 2008; Hanna et al., 2009;…”
- Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity of Mammalian Proteomes (2011, background): “Withdrawal of leukemia inhibitory factor (LIF) induced differentiation (Figure S4A), which we assessed visually and by the downregulation of the direct LIF target Klf4 (Niwa et al., 2009), followed by loss of Oct4 expression and the induction of developmental and lineage-specific genes (Figures S4B ”
- Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human (2014, background): “Mouse ESC can withstand Tfcp2l1 depletion due to compensation by Esrrb (Martello et al., 2013).”