Effectiveness-implementation Hybrid Designs

By Geoffrey Curran, M. Bauer, Brian S. Mittman, J. Pyne, C. Stetler. Medical Care, 2012

2,745 citations recorded by the source corpus.

Objectives:This study proposes methods for blending design components of clinical effectiveness and implementation research. Such blending can provide benefits over pursuing these lines of research independently; for example, more rapid translational gains, more effective implementation strategies, and more useful information for decision makers. This study proposes a “hybrid effectiveness-implementation” typology, describes a rationale for their use, outlines the design decisions that must be faced, and provides several real-world examples. Results:An effectiveness-implementation hybrid design is one that takes a dual focus a priori in assessing clinical effectiveness and implementation. We propose 3 hybrid types: (1) testing effects of a clinical intervention on relevant outcomes while observing and gathering information on implementation; (2) dual testing of clinical and implementation interventions/strategies; and (3) testing of an implementation strategy while observing and gathering information on the clinical intervention’s impact on relevant outcomes. Conclusions:The hybrid typology proposed herein must be considered a construct still in evolution. Although traditional clinical effectiveness and implementation trials are likely to remain the most common approach to moving a clinical intervention through from efficacy research to public health impact, judicious use of the proposed hybrid designs could speed the translation of research findings into routine practice.

Subfields: General Health Professions

View Paper: https://www.semanticscholar.org/paper/6dbdde3fe59c3f37406d5bdc0ac5958d3e9f001c

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In General Health Professions

Citations in the corpus

Qualitative Methods in Implementation Research: An Introduction (2019, methodology): “…that occurs during implementation; the effectiveness of implementation strategies (i.e., “methods or techniques used to enhance the adoption, implementation, and sustainability of a clinical practice or program”; Curran et al., 2012); and the relationship(s) between theorized and actual changes.”
An Introduction to Effectiveness-Implementation Hybrid Designs (2019, methodology): “…efficacy-effectiveness-implementation silos and/or bridging the practice-based/research-based divide (Brownson et al., 2013; Chambers et al., 2013; Chambers and Norton, 2016; Curran et al., 2012a; Glasgow et al., 2003; Green, 2006; Owen et al., 2012; Wells, 1999; Wiltsey Stirman et al., 2013).”
Experimental and Quasi-Experimental Designs in Implementation Research (2019, background): “Hybrid implementation-effectiveness studies attend to both effectiveness and implementation outcomes (Curran et al., 2012); these designs are also covered in more detail elsewhere in this issue (Landes, this issue).”
Psychometric assessment of three newly developed implementation outcome measures (2017, background): “Indeed, with an increasing focus on designing for dissemination and implementation [29], and some going as far as to say that all effectiveness studies be Hybrid I effectivenessimplementation studies [30, 31], measuring constructs such as acceptability, appropriateness, and feasibility will be a ubi”
An introduction to implementation science for the non-specialist (2015, background): “Hybrid research designs are defined as trial designs that take a dual focus a priori of assessing both the effectiveness of the implementation strategy in enhancing the use of the EBP and the health impact of the EBP [63].”
Selecting and Improving Quasi-Experimental Designs in Effectiveness and Implementation Research (2018, background): “Such blending of effectiveness and implementation components within a study can provide benefits beyond either research approach alone (14), for example by leading to faster uptake of interventions by simultaneously testing implementation strategies.”
Purposeful Sampling for Qualitative Data Collection and Analysis in Mixed Method Implementation Research (2015, methodology): “2003), effectiveness-implementation hybrid designs provide benefits such as more rapid translational gains in clinical intervention uptake, more effective implementation strategies, and more useful information for researchers and decision makers (Curran et al. 2012).”
Implementation science: What is it and why should i care? (2020, neutral): “(Curran et al., 2012; and see Kirchner, this issue) While the subject population and setting in an implementation trial may resemble those used in effectiveness trials, alternatively the unit of observation in implementation trials may also be providers or clinics or even entire…”
An Overview of Research and Evaluation Designs for Dissemination and Implementation (2017, background): “We note three broad types not discussed: those where effectiveness of the clinical preventive intervention is to be evaluated alongside questions involving implementation, which include hybrid designs (36) and continuously evolving interventions (72), those designs that address quality improvement f”
Digital Mental Health Interventions for Depression, Anxiety, and Enhancement of Psychological Well-Being Among College Students: Systematic Review (2018, positive): “…for college students, digital health researchers need to embrace methods and models from implementation science, such as hybrid trial designs [153], and add to the body of knowledge on how to create and support a campus mental health system that actively uses digital mental health programs.”
Three Problems With Current Digital Mental Health Research … and Three Things We Can Do About Them (2017, background): “This can be achieved through hybrid trial designs that integrate simultaneous testing of treatment effects and implementation models (8).”