Action potential generation requires a high sodium channel density in the axon initial segment

By Maarten H. P. Kole, S. Ilschner, B. Kampa, Stephen R. Williams, P. Ruben, G. Stuart. Nature Neuroscience, 2008

672 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6da93c591f95557b9809b5cfe456ca0aff3c3be8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Idan Segev
2. Felix Schürmann
3. Sean L. Hill
4. Etay Hay
5. Hua Hu
6. J. Gan
7. Henning Sprekeler
8. Susanne Schreiber

In Molecular Biology

1. Andrew P. Davison
2. Peter Jonas
3. Henry Markram
4. Maarten H. P. Kole
5. Idan Segev
6. G. Stuart
7. Michael L. Hines

Citations in the corpus

• NeuroML: A Language for Describing Data Driven Models of Neurons and Networks with a High Degree of Biological Detail (2010, methodology): “Models with detailed neuronal morphologies, Hodgkin-Huxley type voltage-gated membrane conductances, and phenomenological synaptic inputs have been used to explore the determinates of action potential firing patterns and information processing in single neurons [1–10].”
• Inhibition as a Binary Switch for Excitatory Plasticity in Pyramidal Neurons (2016, background): “25 S/cm(2)) based on modern sodium imaging techniques [80]).”
• Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties (2011, methodology): “The estimates for kinetics parameters such as VK values differ considerably in different studies [32,55,57], by 5–15 mV on average.”
• Fast-spiking, parvalbumin+ GABAergic interneurons: From cellular design to microcircuit function (2014, background): “This is different from pyramidal neurons, where the initiation site is more remote, sometimes even beyond the axon initial segment (44).”
• Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation (2009, background): “Because immunostaining studies and patch-clamp recordings have indicated a similar density of Na + channels along the length of the AI”
• Signal processing in the axon initial segment. (2012, positive): “Consistent with this idea, much larger Na+ currents are observed in patch-clamp recordings from the AIS after chemical disruption of the actin cytoskeleton (Kole et al., 2008) and in recordings from axon blebs (Hu et al., 2009; Schmidt-Hieber and Bischofberger, 2010).”