Two-component signal transduction.

By Ann M Stock, V. Robinson, P. N. Goudreau. Annual Review of Biochemistry, 2000

2,352 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/6d9f5d9de0058f01576dccfc2ff9ddbed2a664f7

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Citations in the corpus

The Biology of Streptococcus mutans (2019, background): “…a signal is sent by phosphotransfer between histidine senor kinases and their cognate response regulators, triggering the response regulators to dimerize and bind to conserved DNA motifs, ultimately tuning cellular functions such as bio ﬁ lm formation, stress tolerance, and nutrient uptake (91).”
Dimerization allows DNA target site recognition by the NarL response regulator (2002, background): “gif" NDATA ITEM> ]> The NarL transcription factor from Escherichia coli is an archetypal member of the large and diverse two-component signal transduction system of response regulation found in most prokaryotes and some lower eukaryote”
Fast and Accurate Multivariate Gaussian Modeling of Protein Families: Predicting Residue Contacts and Protein-Interaction Partners (2014, neutral): “In both cited papers, bacterial two-component signal transduction systems (TCS) were chosen, which constitute a major way by which bacteria sense their environment, and react to it [34].”
Novel domains of the prokaryotic two-component signal transduction systems. (2001, background): “His kinase 1 V80 phosphoacceptor, dimerization 1joy HisKA 0642d PF00512 [14,15,17] His kinase 2 V120 Phosphorylation of His kinase 1 domain 1bxd HATPase 0642d PF02518 [14,15,17] Hpt V100 phosphoacceptor 2a0b HPT 2198 PF01627 [6,14] Response moduleb CheY V120 phosphoacceptor 2che REC 0784 PF00072 [15”
Allostery and cooperativity revisited (2008, background): “Chemotaxis protein Y (CheY) is a prototypical response regulator in bacterial chemotaxis (Stock et al. 2000), and is highly homologous to the protein NtrC studied by recent NMR experiments (Volkman et al. 2001).”
Features of protein-protein interactions in two-component signaling deduced from genomic libraries. (2007, background): “In short, the ultimate association between signal and response is achieved through a transient phosphotransfer interaction between the HisKA and RR proteins (Hoch, 2000; Ninfa et al., 1988; Parkinson, 1993; Stock et al., 1989, 2000 ).”
Type-A Arabidopsis Response Regulators Are Partially Redundant Negative Regulators of Cytokinin Signaling Online version contains Web-only data. (2004, background): “A simple twocomponent system involves a His sensor kinase and a response regulator (Stock et al., 2000; West and Stock, 2001).”