Low Relative Skeletal Muscle Mass (Sarcopenia) in Older Persons Is Associated with Functional Impairment and Physical Disability

By Ian Janssen, Steven B. Heymsfield, R. Ross. Journal of The American Geriatrics Society, 2002

3,111 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/6d76f74c4257d249c8762150d8913f407640ccb6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

In Physiology

Citations in the corpus

Sarcopenia: Its assessment, etiology, pathogenesis, consequences and future perspectives (2008, methodology): “Hôpital La Grave-Casselardit, 31300 Toulouse, France, Telephone: (33) 5 61 77 74 65, Fax: (33) 5 61 49 71 09, rolland.”
The Healthcare Costs of Sarcopenia in the United States (2004, result): “, chronic disease) have a greater effect in women than men, consistent with the knowledge that the prevalence of disability is higher in women.(6,9,10,11) The healthcare cost estimates only took into consideration the direct costs of sarcopenia, including hospital, outpatient, and home healthcare ex”
Pitfalls in the measurement of muscle mass: a need for a reference standard (2018, positive): “Both SMI definitions have previously been shown to predict disability and functional limitations in large, epidemiologic studies of older adults.(8,86,87) However, the classification of communitydwelling older adults as sarcopenic or non-sarcopenic differed markedly for the two definitions.”
Prognostic Value of Usual Gait Speed in Well‐Functioning Older People—Results from the Health, Aging and Body Composition Study (2005, background): “A significant relationship between low skeletal muscle mass, functional impairment, and disability has been demonstrated.(25) Moreover, obesity, another condition associated with inflammation, is strongly associated with disability, especially lower-body disability.”
Role of the nervous system in sarcopenia and muscle atrophy with aging: strength training as a countermeasure (2010, background): “4(a)] and the resulting reduction in mechanical muscle output leads to a loss in function (Janssen et al., 2002; Buchman et al., 2007) during typical activities of daily living such as rising from a chair, stair walking, and in postural balance control (Tinetti et al., 1988; Bassey et al., 1992;…”
Frailty Assessment in the Cardiovascular Care of Older Adults (2013, background): “Muscle mass is a predictor of frailty and functional decline (86,87) and can be reliably measured by computed tomography, magnetic resonance, or dual-isotope x-ray absorptiometry (88).”
Sarcopenia: Alternative Definitions and Associations with Lower Extremity Function (2003, result): “Some have shown that higher fat mass is a more important factor than low LM,(15,16) whereas others have found an independent effect of low lean mass on impaired functional status.(4,5,17) These other studies found more similar associations between kg/ ht(2) and function in men and women.”
Clinical definition of sarcopenia. (2014, background): “Muscle mass decrease is directly responsible for functional impairment with loss of strength, increased likelihood of falls, and loss of autonomy (4, 5).”
Sarcopenia: European consensus on definition and diagnosis (2010, methodology): “[67] also used standard deviations to define sarcopenia, measured in terms of skeletal muscle index (SMI), where SMI = (skeletal muscle mass/ body mass) × 100.”
Molecular Inflammation: Underpinnings of Aging and Age-related Diseases (2008, background): “While an important correlate of impairment and physical disability in older persons (Villareal et al., 2004), it is associated with a decrease in muscular strength and endurance and a loss of autonomy in older persons (Janssen et al., 2002).”
Frailty Syndrome: A Transitional State in a Dynamic Process (2009, background): “If tasks are perceived as more difficult, the likelihood of avoidance of physical effort is increased, and as more occasions of physical effort are avoided, exercise performance continues to decline, contributing to additional physiological decrements in functional reserve capacity, leading to more ”
Sarcopenia, Dynapenia, and the Impact of Advancing Age on Human Skeletal Muscle Size and Strength; a Quantitative Review (2012, methodology): “According to the definition of Janssen et al. (2002) described above, in a study using a nationally representative cohort of Americans, 50% of men and 72% of women over 80 years were sarcopenic; with 7 and 11% suffering Class II sarcopenia.”
Sarcopenia in an Overweight or Obese Patient Is an Adverse Prognostic Factor in Pancreatic Cancer (2009, background): “However, BMI has clear limitations, and more detailed evaluation of body composition clearly revealed wasting of the lean tissues, with a majority of patients below or well below benchmark levels of muscularity known to be associated with mortality and functional disability (21).”