Clinical Pharmacokinetics of Metformin

By G. Graham, J. Punt, M. Arora, R. Day, M. Doogue, J. Duong, T. Furlong, J. Greenfield, L. Greenup, C. Kirkpatrick and 3 more. Clinical Pharmacokinetics, 2011

1,398 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/6d5f4abe97ad2de7f2f29483f6b928aa6408544c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. Traci E LaMoia
2. Gerald I. Shulman
3. Ralph DeFronzo
4. C. Bailey
5. Nur Samsu
6. D. Hardie
7. I. Tabas
8. K. Bornfeldt

In Molecular Biology

1. Gerald I. Shulman
2. Ralph DeFronzo
3. D. Hardie
4. Traci E LaMoia
5. B. Viollet
6. R. Shaw
7. David M. Sabatini
8. K. Guan

In Oncology

1. Ralph DeFronzo
2. Nur Samsu
3. D. Hardie

Citations in the corpus

• The mechanisms of action of metformin (2017, background): “small intestine with the remainder passing into the colon before being excreted in faeces [4].”
• Metformin-associated lactic acidosis: Current perspectives on causes and risk. (2016, background): “have a bioavailability of ~50%–60%; metformin circulates in the plasma unbound and is eliminated unchanged by the kidneys [3,19].”
• Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis (2014, neutral): “DOI: 10.7554/eLife.02242 16 of 18 Research article between 0.5 µg/ml and 2 µg/ml (Graham et al., 2011).”
• Cellular and molecular mechanisms of metformin: an overview. (2012, background): “Wang, Z.J., Yin, O.Q., Tomlinson, B., and Chow, M.S. (2008) OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine.”
• Cellular and Molecular Mechanisms of Metformin Action (2020, background): “Patients prescribed metformin receive doses of 1 g/day to 2 g/day [or ~20 mg/(kg-day)], leading to plasma metformin concentrations of ~10 µ M to ~40 µ M (46-49).”
• Metformin: historical overview (2017, background): “It is not metabolised and is excreted in the urine unchanged, with approximately 20% of the drug being filtered, with the remaining ∼80% being secreted by the kidney [92]”
• A Comprehensive Review of Drug–Drug Interactions with Metformin (2015, background): “maximum plasma concentration (Cmax) after 2–3 h [18].”
• Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment (2021, background): “the kidneys [147], the plasma concentration in patients with renal impairment will increase so that metformin is contraindicated in these individuals.”