Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

By P. Eerdewegh, R. D. Little, J. Dupuis, R. D. Mastro, K. Falls, J. Simon, D. Torrey, Sunil Pandit, Joyce McKenny, K. Braunschweiger and 28 more. Nature, 2002

1,120 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/6d5cb422ed898060c6bde51fe1edf085fca2563f

How researchers see this paper

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In Molecular Biology

1. C. Blobel
2. D. Edwards
3. S. Eguchi
4. H. Ohtsu
5. P. Dempsey
6. M. Handsley
7. C. Pennington
8. Mark J. Daly

In Oncology

1. C. Blobel
2. D. Edwards
3. S. Eguchi
4. H. Ohtsu
5. P. Dempsey
6. M. Handsley
7. C. Pennington

Citations in the corpus

• The ADAMs family of metalloproteases: multidomain proteins with multiple functions. (2003, background): “Van Andel Research Institute, Grand Rapids, Michigan 49503, USA The ADAMs family of transmembrane proteins belongs to the zinc protease superfamily.”
• The ADAM metalloproteinases (2008, background): “Linkage studies identified ADAM33 as a candidate asthma-susceptibility locus, and numerous polymorphisms were identified in both coding and non-coding regions, the latter suggestive of effects on splicing or transcriptional control (Van Eerdewegh et al., 2002).”
• Effect of active vitamin D3 on VEGF-induced ADAM33 expression and proliferation in human airway smooth muscle cells: implications for asthma treatment (2017, background): “A disintegrin and metalloproteinase (ADAM)33, a recently discovered ADAM family member, has been found to play a role in the pathophysiology of asthma [7].”
• Haploview: analysis and visualization of LD and haplotype maps (2005, background): “…common haplotype patterns in disease association and positional cloning studies is becoming increasingly widespread since it has become clear (Van Eerdewegh et al., 2002; Rioux et al., 2001; Geesaman et al., 2003; Stoll et al., 2004) that intelligent use of this information has the potential to…”
• Metalloprotease‐disintegrin ADAM8: Expression analysis and targeted deletion in mice (2005, background): “Finally, mutations in the ADAM33 gene have been linked to asthma and bronchial hyperresponsiveness in humans (Van Eerdewegh et al., 2002).”
• Catalytic Activity of Human ADAM33* (2004, background): “…of ‡Allergy and ¶Structural Chemistry, Schering-Plough Research Institute, Kenilworth, New Jersey 07033 ADAM33 (a disintegrin and metalloproteinase) is an asthma susceptibility gene recently identified through a genetic study of asthmatic families (van Eerdewegh et al. (2002) Nature 418, 426–430).”
• Essential roles of Meltrin β (ADAM19) in heart development (2004, background): “1998; Huang et al., 2003; Kurisaki et al., 2003; Peschon et al., 1998; Rooke et al., 1996; Yagami-Hiromasa et al., 1995) and are implicated in certain pathogeneses (Asakura et al., 2002; Van Eerdewegh et al., 2002).”
• Identifying SNPs predictive of phenotype using random forests (2005, background): “ADAM33 is an asthma susceptibility gene identified using a positional cloning approach [Van Eerdewegh et al., 2002].”
• ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. (2006, background): “ADAM33 was identified as being significantly associated with asthma and bronchial hyperresponsiveness by using positional cloning to search for disease-causing gene (107).”