Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode α1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis

By Byung-Taek Kim, H. Kitagawa, J. Tamura, Toshiyuki Saito, M. Kusche‐Gullberg, U. Lindahl, K. Sugahara. 2001

194 citations recorded by the source corpus.

Subfields: Cell Biology, Hematology, Molecular Biology

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In Cell Biology

1. S. Yamada

In Hematology

1. S. Yamada

In Molecular Biology

1. R. Wanders
2. S. Yamada

Citations in the corpus

• The exostosin family: proteins with many functions. (2014, unknown): “1) (Kim et al., 2001).”
• Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome. (2017, background): “EXTL2 shares GlcNac-TI activity with EXTL3 but initiates HS chains on different core proteins than EXTL3 by discriminating the amino acid sequences.(9) EXTL1 is involved in the elongation of HS chains by exhibiting GlcNAcT-II activity,(9) whereas the EXT family members EXT1 andEXT2 formaheterooligom”
• Specific functions of Exostosin-like 3 (EXTL3) gene products (2020, methodology): “catalyze the chain elongation reactions of HS polysaccharides [13, 14].”