The exostosin family: proteins with many functions.
By Marta Busse-Wicher, K. Wicher, M. Kusche‐Gullberg. 2014
122 citations recorded by the source corpus.
Heparan sulfates are complex sulfated molecules found in abundance at cell surfaces and in the extracellular matrix. They bind to and influence the activity of a variety of molecules like growth factors, proteases and morphogens and are thus involved in various cell-cell and cell-matrix interactions. The mammalian EXT proteins have glycosyltransferase activities relevant for HS chain polymerization, however their exact role in this process is still confusing. In this review, we summarize current knowledge about the biochemical activities and some proposed functions of the members of the EXT protein family and their roles in human disease.
Subfields: Cancer Research, Cell Biology, Immunology and Allergy
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In Cell Biology
Citations in the corpus
- Specific functions of Exostosin-like 3 (EXTL3) gene products (2020, background): “Gene Chromosomal location Amino acid Sequence identity with EXTL3 (%) [9] mRNA accession number MIM number”
- Glycosyltransferase complexes in eukaryotes: long-known, prevalent but still unrecognized (2015, background): “In addition, coexpression of polylactosamine synthesizing enzymes b3GnT-2 and b3GnT-8 has also been shown to increase the activity of both of these two enzymes in vitro [45] .”