A common variant on chromosome 9p21 affects the risk of myocardial infarction.

By A. Helgadóttir, G. Thorleifsson, A. Manolescu, S. Gretarsdottir, T. Blondal, Á. Jónasdóttir, Abalbjorg Jonasdottir, A. Sigurdsson, A. Baker, Arnar Pálsson and 25 more. Science, 2007

961 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6d0320366e582da5c7dabbd4befb6eaa0c5f2a10

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Citations in the corpus

Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease (2016, neutral): “Diabetes mellitus 632/7799 (8) 519/21,222 (2) 904/22,389 (4) 522/4257 (12)”
The Genetic Signatures of Noncoding RNAs (2009, neutral): “heart disease [106–112].”
Cellular senescence in cancer and aging. (2007, positive): “Recently, genetic variants in the INK4a/ARF locus have been linked to various age-associated diseases, including general frailty, heart failure, and type 2 diabetes (Helgadottir et al., 2007; McPherson et al., 2007; Melzer et al., 2007; Saxena et al., 2007; Scott et al., 2007; Zeggini et al., 2007).”
Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk (2010, background): “disease, stroke, myocardial infarction and aortic aneurysm) [2–12].”
Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4B tumor suppressor gene (2010, background): “Recent genome-wide association studies have linked common single-nucleotide polymorphisms in 9p21 region that is independently associated with both type II diabetes and coronary heart disease (Helgadottir et al., 2007; McPherson et al., 2007; Saxena et al., 2007; Scott et al., 2007).”