Human SWI/SNF-Associated PRMT5 Methylates Histone H3 Arginine 8 and Negatively Regulates Expression of ST7 and NM23 Tumor Suppressor Genes
By Sharmistha Pal, Sheethal N Vishwanath, H. Erdjument‐Bromage, Paul Tempst, S. Sif. Molecular and Cellular Biology, 2004
613 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6cef0c611a27506aea9e9bf7674bdeb4ad2caca7
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In Molecular Biology
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Citations in the corpus
- Discovery and Development of the G-rich Oligonucleotide AS1411 as a Novel Treatment for Cancer (2009, background): “One of the reasons why we focused on PRMT5 is that this gene is increasingly being recognized as an oncogene that functions in the nucleus by methylating histone arginines, leading to transcriptional repression of various tumor suppressor genes [168].”
- Epigenetic events in mammalian germ-cell development: reprogramming and beyond (2008, background): “and H3R8me, which is also mediated by PRMT5, can repress transcriptio”
- Targeting the dynamic HSP90 complex in cancer (2010, background): “PRMT5-mediated methylation negatively regulates two tumour suppressor genes, ST7 and NM23 (Ref”
- Late Cornified Envelope Group I, a Novel Target of p53, Regulates PRMT5 Activity (2014, background): “LCE1F Suppresses PRMT5 Activity Since PRMT5 was reported to regulate the transcription of various genes through the methylation of arginine 8 on histone H3 (H3R8), which is considered to play an important role in human carcinogenesis [16,20,21], we further investigated the biologic”
- Cyclin D1, Cancer Progression and Opportunities in Cancer Treatment (2016, background): “PRMT5 symmetrically dimethylates proteins, for example the methylation of histones 3 and 4, resulting in heterochromatinization and transcriptional silencing [101].”
- Protein Arginine Methylation in Mammals: Who, What, and Why (2009, background): “The existence of an H3R8me2a or me2s mark will in turn block G9amediated H3K9 methylation (Rathert et al., 2008).”