The power to reduce: pyridine nucleotides--small molecules with a multitude of functions.

By N. Pollak, Christian Dölle, M. Ziegler. Biochemical Journal, 2007

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Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress (2007, background): “The glycolytic pathway is directly interconnected with the PPP, which is one of the key pathways in reducing the pyridine nucleotide NADP+ to NADPH within the eukaryotic cytoplasm and, hence, one of the main cellular sources of the cytoplasmic NADPH that is required as a redox cofactor by the main a”
NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences (2008, neutral): “Whereas three isoforms of NADKs have been found in yeast, there is only one known NADK in mammals (233).”
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014, background): “A metaanalysis of glucose and oxygen consumption throughout the human lifespan and among different brain regions suggests that non-oxidative glucose utilization may be important during development to support synaptic remodelling (Vaishnavi et al., 2010; Goyal et al., 2014).”