MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F
By Géraldine Mathonnet, M. Fabian, Y. Svitkin, Armen Parsyan, L. Huck, T. Murata, S. Biffo, W. Merrick, E. Darżynkiewicz, R. Pillai and 3 more. Science, 2007
612 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6c26cb6d032fbe60d808a9ee3a7d63c5be235346
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In Cancer Research
- Nahum Sonenberg
- M. Fabian
- Danish H Sayed
- M. Abdellatif
- W. Filipowicz
- Anil Sood
- Gabriel Lopez-Berestein
- M. Cortez
In Molecular Biology
- W. Filipowicz
- Nahum Sonenberg
- Elisa Izaurralde
- M. Fabian
- Yukihide Tomari
- Eric Huntzinger
- Hirotaka Iwakawa
- A. Eulalio
Citations in the corpus
- MicroRNAs in development and disease. (2011, methodology): “A cell-free translation system shows that miRNA inhibits translation via inhibiting the assembly of the 80S ribosomal complex in a cap (m7GpppG)-dependent manner (406).”
- Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets (2009, neutral): “In contrast to the disparate results obtained from studies in cells, in vitro experiments in cell-free translation extracts prepared from mammalian or Drosophila embryos all indicated that miRNAs suppress cap-dependent but not IRES-mediated translation (Mathonnet et al., 2007; Thermann and Hentze, 2”
- MicroRNAs in body fluids—the mix of hormones and biomarkers (2011, positive): “In mammals, gene regulation mediated by miRNAs is accomplished by imperfect base pairing together with protein translational repression of the target gene”
- Getting to the root of miRNA-mediated gene silencing. (2008, background): “…through cap-independent mechanisms (that is, through an IRES) were refractory to repression by miRNAs, further supporting the notion that miRNAs inhibit cap- r Inc. dependent translation initiation (Humphreys et al., 2005; Pillai et al., 2005; Mathonnet et al., 2007; Wakiyama et al., 2007).”
- The Functions of MicroRNAs: mRNA Decay and Translational Repression. (2015, background): “Supplementation or depletion of initiation factors attenuated miRNA-mediated repression [83,85,86,106,109].”