TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation

By Jeong‐Ho Hong, E. Hwang, Michael T. McManus, A. Amsterdam, Yu Tian, Ralitsa Kalmukova, E. Mueller, T. Benjamin, B. Spiegelman, Phillip A. Sharp and 2 more. Science, 2005

1,020 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6bff072b6b4a57fd4556d4485b3474617e490453

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In Molecular Biology

1. K. Guan
2. Fa-Xing Yu
3. Bin Zhao
4. S. Piccolo
5. Randy L. Johnson
6. G. Halder
7. M. Cordenonsi
8. Xaralabos Varelas

Citations in the corpus

• Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation (2013, background): “activation (73), and the IP-MS data suggested a YAP1-TAZ interaction.”
• TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway (2008, background): “TAZ has been reported previously to modulate mesenchymal stem cell differentiation (9).”
• Developmental origin of fat: tracking obesity to its source. (2007, positive): “domain-containing transcriptional modulator, which acts similarly to β-catenin and modulates MSC fate favoring osteogenic gene transcription, while repressing PPARγ-dependent adipogenic gene transcription (Hong et al., 2005).”
• Effects of dexamethasone, ascorbic acid and β-glycerophosphate on the osteogenic differentiation of stem cells in vitro (2013, background): “Zebrafish that were TAZ-depleted did not form bone, providing further evidence for the importance of TAZ in osteoblast differentiation [18].”
• The Hippo Signaling Pathway in Development and Cancer (2010, background): “Likewise, TAZ has been reported to interact with multiple DNA-binding transcription factors, such as peroxisome proliferator-activated receptor g (Hong et al., 2005), thyroid transcription factor-1 (Park et al., 2004), Pax3 (Murakami et al., 2006), Tbx5 (Murakami et al., 2005), Runx2 (Cui et al.,…”
• The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease (2014, background): “3) (Dupont et al., 2011; Hong et al., 2005).”