Chemokines and their receptors: drug targets in immunity and inflammation.

By A. Viola, A. Luster. Annual Review of Pharmacology and Toxicology, 2008

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Orchestrating the orchestrators: chemokines in control of T cell traffic (2008, background): “213" language="eng" publish="issue" relation="no"> It is now firmly established that chemokines serve a central function in the immune system by coordinating the localization of immune cells in the body to generate an immune response at specific anatomic site”
Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells (2011, background): “Leukocyte migration into inflamed tissues, as in cancer, is driven by chemokines, small cytokines with selective chemoattractant properties (Viola and Luster, 2008).”
DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation. (2020, background): “However, many promising molecules proved to be non-beneficial in chronic inflammatory diseases (12), providing support for the need for further mechanistic insight.”