The noncoding RNA revolution-trashing old rules to forge new ones.

By T. Cech, J. Steitz. Cell, 2014

2,210 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6bf52f85387482ad4bf649861134d04fbfcea614

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In Molecular Biology

Citations in the corpus

RNA duplex map in living cells reveals higher order transcriptome structure (2016, background): “Structured RNAs are critical components of key molecular machines in the cell, such as the spliceosome, ribosome, and telomerase, and RNA structures play important roles in the control of mRNA and noncoding RNA functions (Cech and Steitz, 2014).”
Non-coding RNA: what is functional and what is junk? (2015, neutral): “There are still other more exotic species of RNAs (Cech and Steitz, 2014), including circular RNAs (Wilusz and Sharp, 2013).”
Epigenetics and aging (2016, background): “Although it is likely that the majority of these functions are epigenetic, with the ncRNAs having significant influence on modulating gene expression and chromatin packaging, the complete array of biological functions of ncRNAs is yet to be understood (170, 171).”
Trends in insulin resistance: insights into mechanisms and therapeutic strategy (2022, background): “non-coding RNA regulation in IR Non-coding RNAs (ncRNAs) comprise approximately 98% of human genome transcripts and are generally not translated into proteins.(233) The rising studies(234,235) have shown that ncRNAs include microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRN”
Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood (2015, background): “Regulatory RNAs such as microRNAs (miRNAs) or long non-coding RNAs (lncRNAs) have been implicated in many biological processes and human diseases such as cancer (reviewed in [1,2].”
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation (2014, background): “Even less is known about the biological roles of most noncanonical transcripts such as enhancer RNAs, upstream antisense RNAs, lncRNAs, or other intergenic RNAs (Cech and Steitz, 2014).”
A census of human RNA-binding proteins (2014, background): “, 2012) or regulation (Cech and Steitz, 2014), as well as mechanisms of RNA/RNP clearance, remain poorly understood.”