A pathophysiological framework of hippocampal dysfunction in ageing and disease

By Scott A. Small, S. Schobel, Richard B. Buxton, Menno P. Witter, C. A. Barnes. Nature Reviews Neuroscience, 2011

943 citations recorded by the source corpus.

The hippocampal formation has been implicated in a growing number of disorders, from Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the hippocampal formation, a complex circuit that spans the temporal lobes, be involved in a range of such phenotypically diverse and mechanistically distinct disorders? Recent neuroimaging findings indicate that these disorders differentially target distinct subregions of the hippocampal circuit. In addition, some disorders are associated with hippocampal hypometabolism, whereas others show evidence of hypermetabolism. Interpreted in the context of the functional and molecular organization of the hippocampal circuit, these observations give rise to a unified pathophysiological framework of hippocampal dysfunction.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/6bc6decf17d941898df994d72271ad333e216c93

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Age Differences in Hippocampal Subfield Volumes from Childhood to Late Adulthood (2015, background): “KEY WORDS: development; aging; CA1; dentate gyrus; entorhinal cortex INTRODUCTION The hippocampus has long been a focus of research of normal and pathological development in many mammalian species (see Small et al., 2011 for a review).”
A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI (2015, positive): “Neuroimaging studies that have characterized the subregions in normal aging and AD with in vivo MRI include (Mueller et al., 2007; Wang et al., 2009; Mueller et al., 2010; Small et al., 2011; Kerchner et al., 2012; Wisse et al., 2012, 2014; Burggren et al., 2008).”
Quantitative Comparison of 21 Protocols for Labeling Hippocampal Subfields and Parahippocampal Subregions in In Vivo MRI: Towards a Harmonized Segmentation Protocol (2015, background): “Different psychiatric and neurological disorders are known to affect hippocampal subfields and MTL cortical subregions differently, selectively, and in a complex progression (Braak & Braak, 1995; Arnold et al., 1995; Simić et al., 1997; de Lanerolle et al., 2003; West et al., 2004; Lucassen et al., ”
Age-Related Characteristics of Resting-State Electroencephalographic Signals and the Corresponding Analytic Approaches: A Review (2024, background): “…and neurosteroids (testosterone in men and estrogen in women), in the hippocampal formation leads to the degradation of neural mechanisms across associated regions and may finally cause senile neuropathological disorders, such as dementia, Alzheimer’s disease and Parkinson’s disease [4,12,13].”