Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

By Ji‐Hoon Lee, T. Paull. Science, 2004

826 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6b8dbee93cd505d3d12496f731e6efa62d0d2a84

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5. C. Lukas
6. Zhi Guo
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8. S. Kozlov

Citations in the corpus

• Checking on DNA damage in S phase (2004, background): “Indeed, the MRN complex makes several direct contacts with ATM in vitro”
• The MRE11 complex: starting from the ends (2011, methodology): “Whereas NBS1 was dispensable for ATM activation in vitro using purified human MRE11 and RAD50 (Ref”
• Cell-cycle checkpoints and cancer (2004, background): “It was recently demonstrated that MRE11 binds to ATM and enhances its ability to phosphorylate substrates in vitro in the presence of an appropriate mimic of DNA break”
• ATM Activation by Oxidative Stress (2010, background): “The MRN complex activates ATM by promoting ATM dimer dissociation and substate binding [24, 26].”