MAPKK-Independent Activation of p38α Mediated by TAB1-Dependent Autophosphorylation of p38α

By Baoxue Ge, H. Gram, F. D. Di Padova, Betty C. B. Huang, L. New, R. Ulevitch, Ying Luo, Jiahuai Han. Science, 2002

517 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6b7cab6fcca8b8338a11ba67572aba000410ced3

How researchers see this paper

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In Cancer Research

1. J. Avruch
2. Hao Wu
3. J. Kyriakis

In Molecular Biology

1. M. Ståhlman
2. J. Avruch
3. Hao Wu
4. F. Bäckhed
5. A. Koh
6. Josef M. Penninger
7. J. Corbin
8. T. Wada

Citations in the corpus

• Mitogen-activated protein kinases in apoptosis regulation (2004, background): “Although those previously known upstream molecules are kinases, it has been recently shown that nonprotein kinase TAB1 can activate p38MAPK (Ge et al., 2002). p38-MAPK signaling pathways are involved in a variety of cellular responses, and the outcomes of cellular response are varied and…”
• Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1. (2018, background): “Although upstream kinase-mediated p38 phosphorylation is the conventional mechanism to activate p38, there are studies that support p38 autophosphorylation and thus suggest that p38 can activate itself (Ashwell, 2006; Beenstock et al., 2014; Ge et al., 2002; Kim et al., 2005).”
• p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases (2003, background): “cgi?l=10454">TAB1 (transforming growth factor-β-activated protein kinase 1 (TAK1)-binding protein 1) has been describe”
• cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action (2010, background): “Under conditions of ischemia/reperfusion, p38 MAPK associates with the scaffold protein TAB1 (transforming growth factor- -activated protein kinase 1 binding protein 1), where it undergoes autophosphorylation and activation (Ge et al., 2002; Tanno et al., 2003; Fiedler et al., 2006).”
• Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. (2012, background): “IIID), and may couple p38 to PAMP agonists (93).”