Aberrant CpG-island methylation has non-random and tumour-type–specific patterns
By J. Costello, M. Frühwald, D. Smiraglia, L. Rush, G. Robertson, Xin Gao, Fred A. Wright, J. Feramisco, P. Peltomäki, J. Lang and 13 more. Nature Genetics, 2000
1,409 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6b727291b3d399a794da8fcf4a17a088f0753af4
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Manel Esteller
- S. Baylin
- Peter W. Laird
- Keith D. Robertson
- J. Herman
- J. Christman
- Peter A. Jones
- Melanie Ehrlich
Citations in the corpus
- CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future (2002, background): “The laboratories of Christoph Plass and Joseph Costello have reached the same conclusion using a global genomic methylation scanning (Costello et al., 2000).”
- High-throughput DNA methylation profiling using universal bead arrays. (2006, methodology): “cancers (Huang et al. 1999; Costello et al. 2000).”
- Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. (2001, background): “(3,5,6,8) may serve to identify key genes for tumor development and other biologic processes.”
- 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy (2002, methodology): “These studies also provide evidence for tumor specific patterns of CpG island methylation, with the percentage of CpG island methylation in individual tumors varying from 0 – 10% of the *45 000 CpG islands in the human genome (Costello et al., 2000).”
- Cancer epigenetics. (2005, background): “The large estimated number of epigenetic alterations found in cancer cells (84,132) raises the question whether these reflect stochastic occurrences that accumulate with age, and are selected for during malignant outgrowth, or whether the large number of changes is caused by a defect in one of the c”
- Epigenetic gene silencing in cancer: the DNA hypermethylome. (2007, background): “Another conclusion is that there is a clear gradient in the distribution of tumors with different degrees of CpG island methylation (55,56).”