Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
By J. Odegaard, A. Chawla. Science, 2013
657 citations recorded by the source corpus.
Metabolism and immunity are inextricably linked both to each other and to organism-wide function, allowing mammals to adapt to changes in their internal and external environments. In the modern context of obesogenic diets and lifestyles, however, these adaptive responses can have deleterious consequences. In this Review, we discuss the pleiotropic actions of inflammation and insulin resistance in metabolic homeostasis and disease. An appreciation of the adaptive context in which these responses arose is useful for understanding their pathogenic actions in disease.
Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Physiology
View Paper: https://www.semanticscholar.org/paper/6b6e02a924e3a174f0e9333e90c3ecdbbcb5682c
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cardiology and Cardiovascular Medicine
In Epidemiology
In Physiology
Citations in the corpus
- Homeostasis, Inflammation, and Disease Susceptibility (2015, neutral): “During pregnancy, critical illness, infection, and stress, insulin responsiveness is diminished, presumably to allocate resources toward a growing fetus, tissue repair, or the immune system, respectively (Odegaard and Chawla, 2013; Power and Schulkin, 2012; Watve and Yajnik, 2007).”
- Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines (2013, neutral): “Although liver and muscle show obesity-induced mild inflammatory responses, white adipose tissue (WAT) is the key site mediating systemic inflammation [6].”
- Adipokines Mediate Inflammation and Insulin Resistance (2013, background): “…responses without significant numeric changes of immune cells, adipose tissue depots are the most vulnerable target to mediate significant immune cells infiltration and inflammation contributing to systemic inflammation and insulin resistance in obese rodents and humans (Odegaard and Chawla, 2013).”
- Cellular and Molecular Players in Adipose Tissue Inflammation in the Development of Obesity-induced Insulin Resistance (2013, positive): “This notion is also strongly supported by studies examining the effects of genetic modulation of specific inflammatory mediators in immune cells [5,41,42].”
- Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease (2019, background): “Low-grade inflammation in adipose tissue and liver is a common feature of obesity and metabolic syndrome (Franceschi et al., 2018; Hotamisligil, 2017; Mori et al., 2010; Odegaard and Chawla, 2013).”