Cord Serum Concentrations of Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) in Relation to Weight and Size at Birth
By Benjamin Apelberg, F. Witter, Julie B. Herbstman, A. Calafat, R. Halden, L. Needham, L. Goldman. Environmental Health Perspectives, 2007
632 citations recorded by the source corpus.
Background Recent studies have reported developmental toxicity among rodents dosed with perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA). Objectives We examined the relationship between concentrations of PFOS and PFOA in cord serum (surrogates for in utero exposures) and gestational age, birth weight, and birth size in humans. Methods We conducted a hospital-based cross-sectional epidemiologic study of singleton deliveries in Baltimore, Maryland. Cord serum samples (n = 293) were analyzed for PFOS and PFOA by online solid-phase extraction, coupled with reversed-phase high-performance liquid chromatography–isotope dilution tandem mass spectrometry. Maternal characteristics and anthropometric measures were obtained from medical charts. Results After adjusting for potential confounders, both PFOS and PFOA were negatively associated with birth weight [per ln-unit: β = −69 g, 95% confidence interval (CI), −149 to 10 for PFOS; β = −104 g, 95% CI, −213 to 5 for PFOA], ponderal index (per ln-unit: β = −0.074 g/cm3 × 100, 95% CI, −0.123 to −0.025 for PFOS; β = −0.070 g/cm3 × 100, 95% CI, −0.138 to −0.001 for PFOA), and head circumference (per ln-unit: β = −0.32 cm, 95% CI, −0.56 to −0.07 for PFOS; β = −0.41 cm, 95% CI, −0.76 to −0.07 for PFOA). No associations were observed between either PFOS or PFOA concentrations and newborn length or gestational age. All associations were independent of cord serum lipid concentrations. Conclusions Despite relatively low cord serum concentrations, we observed small negative associations between both PFOS and PFOA concentrations and birth weight and size. Future studies should attempt to replicate these findings in other populations.
Subfields: Environmental Chemistry, Health, Toxicology and Mutagenesis, Water Science and Technology
View Paper: https://www.semanticscholar.org/paper/6b56ab3e3970963b896e3ab2de5ef444c485ce50
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Citations in the corpus
- Endocrine disruptors: from endocrine to metabolic disruption. (2011, background): “In a reference study in the United States, as many as 95% of human urine samples contained detectable levels of BPA in a range that is predicted to be biologically active (38, 57).”
- Epidemiologic Evidence on the Health Effects of Perfluorooctanoic Acid (PFOA) (2010, neutral): “Other indices of fetal growth have been examined in isolated studies with suggestions of adverse effects of PFOA on head circumference and ponderal index (Apelberg et al. 2007) and on abdominal circumference and birth length (Fei et al.”
- Polyfluoroalkyl Chemicals in the U.S. Population: Data from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and Comparisons with NHANES 1999–2000 (2007, neutral): “1596 VOLUME 115 | NUMBER 11 | November 2007 • Environmental Health Perspectives”
- Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort (2007, background): “However, a recent study reported levels of both PFOS and PFOA to be inversely associated with birth weight, newborn head circumference, crown–heel length, and ponderal index, but the study was based on cord blood samples taken after delivery (Apelberg et al. 2007b).”