Directing cell motions on micropatterned ratchets

By Goher Mahmud, C. Campbell, K. Bishop, Y. Komarova, O. Chaga, Siowling Soh, Sabil Huda, K. Kandere-Grzybowska, B. Grzybowski. 2009

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Micropatterning as a tool to decipher cell morphogenesis and functions (2010, unknown): “When triangular shapes are used as a micropattern, cells form actin-based membrane protrusions at cell apices and an alignment of triangles will guide sequential cell movement from one triangle to the next (Mahmud et al., 2009).”
Active Particles in Complex and Crowded Environments (2016, background): “Experimental studies of crawling cells also showed that it is possible for one species of cells to ratchet in one direction through an asymmetric environment while another species of cells ratchets in the opposite direction (Mahmud et al., 2009).”
2D and 3D cell cultures – a comparison of different types of cancer cell cultures (2016, background): “The changed morphology of the cells can affect their function [16, 17], the organization of the structures inside the cell, secretion and cell signalling [18, 19].”
Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, background): “In addition to the total area of spreading, the geometric shape (e.g. circular versus star-shaped, cuboidal versus elongated) that is assumed by the cell can impact its function (Brock et al., 2003; Théry et al., 2006; Théry et al., 2007; Mahmud et al., 2009; Kilian et al., 2010).”