Renal fibrosis: new insights into the pathogenesis and therapeutics.

By Youhua Liu. Kidney International, 2006

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The myofibroblast: paradigm for a mechanically active cell. (2010, background): “Myofibroblast-generated contractures are also fundamental in organ fibrosis, affecting liver (Gressner and Weiskirchen, 2006; Iredale, 2007), heart (Baudino et al., 2006; Brown R.D. et al., 2005), lung (Phan, 2002; Thannickal et al., 2004) and kidney (Liu, 2006) with often lethal consequences.”
The pancreatic stellate cell: a star on the rise in pancreatic diseases. (2007, background): “Stellate cells derive their name from their shape ( stella in Latin means “a star”) (Figure 1) and are also present in several other organs, including the kidney (23) and lung (24).”
Inflammation and EMT: an alliance towards organ fibrosis and cancer progression (2009, background): “…is the link between the progressive loss of renal function and primary diseases such as glomerulonephritis, diabetes, toxic injury, congenital abnormalities, urinary tract obstruction and chronic rejection of transplanted kidneys (Kalluri & Neilson, 2003; Liu, 2006; Vongwiwatana et al, 2005).”