Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia

By Sheng-Kwei Song, Shu-wei Sun, W. Ju, Shiow J. Lin, A. Cross, A. Neufeld. NeuroImage, 2003

1,824 citations recorded by the source corpus.

Subfields: Pathology and Forensic Medicine, Psychiatry and Mental health, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/6aee5c58dff9a131a6ef60add27762eee993656a

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In Pathology and Forensic Medicine

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Citations in the corpus

Brain maturation in adolescence and young adulthood: regional age-related changes in cortical thickness and white matter volume and microstructure. (2010, background): “Cerebral Cortex March 2010;20:534--548 doi:10.1093/cercor/bhp118 Advance Access publication June 11, 2009”
Apparent Fibre Density: A novel measure for the analysis of diffusion-weighted magnetic resonance images (2012, background): “However, we point out that increased radial diffusivity has been observed during demyelination (Song et al., 2003), which would be detected as a decrease in AFD.”
Decreased white matter integrity in late-myelinating fiber pathways in Alzheimer's disease supports retrogenesis (2008, background): “Preliminary studies suggest that examination of directional diffusivities (e.g., axial and radial diffusion) may yield important information about the underlying neuropathology driving differences in FA (Song et al., 2003, 2002; Sun et al., 2005).”
White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study. (2007, background): “Although the specifics are still not well understood, FA is believed to reflect many factors including the degree of myelination and axonal density and/or integrity (Arfanakis et al., 2002; Song et al., 2002b, 2003; Harsan et al., 2006).”
Partial volume effect as a hidden covariate in DTI analyses (2011, background): “…in radial diffusivity (RD, diffusivity perpendicular to the predominant diffusion direction) and axial diffusivity (AD, diffusivity along the predominant diffusion direction) are believed to reflect different microstructural processes in the WM (Pierpaoli et al., 2001; Song et al., 2002, 2003).”
Diffusion tensor imaging of white matter tract evolution over the lifespan (2012, background): “…diffusion may indicate increased myelination, more densely packed axons, or some combination of the two (Beaulieu, 2002; Jones et al., 1999; Song et al., 2003, 2005), whereas parallel diffusion tends to reflect fiber diameter or organization (Takahashi et al., 2000); brain water content…”
Age-related differences in white matter microstructure: Region-specific patterns of diffusivity (2010, background): “Lowered FA and AD (without RD or MD increases) has been reported in both rodents and humans in acute axonal damage involving axon swelling, fragmentation, and organelle accumulation (Concha et al., 2006; Song et al., 2003; Sun et al., 2006).”
Early-stage visual processing and cortical amplification deficits in schizophrenia. (2005, result): “Fractional anisotropy deficits can be produced by primary glial or neuronal pathology with patterns determined by radial and axial diffusivity.(57) Our study is also consistent with previous findings of decreased functional magnetic resonance imaging activation in thalamus in response to visual and ”
Regional DTI differences in multiple sclerosis patients (2009, positive): “A retinal ischemia model found decreased axial diffusivity to be linked to axonal injury (Song et al., 2003).”
Assessing the effects of age on long white matter tracts using diffusion tensor tractography (2009, background): “In contrast, RD describes an average of the eigenvectors perpendicular to the principal direction ( [λ2 + λ3]/2 ) and is assumed to characterize changes associated with myelination or glial cell morphology (Song et al., 2003; Song et al., 2002; Song et al., 2005).”
The Development of Brain White Matter Microstructure (2018, background): “Axial and radial diffusivity from DTI provide increased specificity to axonal integrity, and myelin and fibre density (Song et al., 2003; Song et al., 2002; Song et al., 2005), respectively, than FA or MD.”
Radial Diffusivity Predicts Demyelination in ex-vivo Multiple Sclerosis Spinal Cords (2011, positive): “This finding corroborates previously published histopathology correlation studies in animal models (Song et al., 2002, 2003, 2005).”
DTI measures in crossing-fibre areas: Increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease (2011, result): “As mentioned by the authors of the former study, this result seem indeed in opposition with what is expected from animal models and human corpus callosotomy demonstrating that axonal pathology or transection should result in a decrease in axial diffusivity (Song et al., 2003; Concha et al., 2006 ).”
White matter damage and cognitive impairment after traumatic brain injury (2010, neutral): “BRAIN A JOURNAL OF NEUROLOGY White matter damage and cognitive impairment after traumatic brain injury”