Tissue-specific mutation accumulation in human adult stem cells during life
By Francis Blokzijl, J. Ligt, M. Jager, Valentina Sasselli, Sophie F. Roerink, Nobuo Sasaki, Meritxell Huch, S. Boymans, E. Kuijk, Pjotr Prins and 18 more. Nature, 2016
849 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/6a87376dc09c19461ad52ed15bdc621efc565568
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In Cancer Research
In Molecular Biology
In Pathology and Forensic Medicine
Citations in the corpus
- Human Primary Liver Cancer -derived Organoid Cultures for disease modelling and drug screening (2017, neutral): “This was in stark contrast to healthy liver-derived organoids that stably 322 maintained diploid chromosome numbers in culture, in agreement with our previous 323 observations [23] [49].”
- Universal Patterns of Selection in Cancer and Somatic Tissues (2018, neutral): “Importantly, similar values of dN/dS around or above one are found in somatic mutations detected in healthy tissues, including blood, skin, liver, colon and small intestine (Blokzijl et al., 2016; Martincorena et al., 2015; Welch et al., 2012) ( Fig.”
- A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. (2018, neutral): “1.7) Cibulskis et al., 2013 https://github.com/broadinstitute/mutect MutationalPatterns R package, release 3.4 Blokzijl et al., 2016a https://github.com/UMCUGenetics/ MutationalPatterns SnpEff (v4.”
- Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations (2018, background): “Emerging cellular therapies where stem cells are harvested and propagated ex vivo can introduce substantial numbers of mutations 21 .”