Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

By A. Khalil, M. Guttman, Maite Huarte, Manuel Garber, Arjun Raj, Dianali Rivea Morales, Kelly Thomas, Aviva Presser, Bradley E. Bernstein, Alexander van Oudenaarden and 3 more. Proceedings of the National Academy of Sciences of the United States of America, 2009

2,927 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6a5b3441861f9243e8a7b8bdba8e2cbca89cdd64

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Citations in the corpus

ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs (2011, positive): “Sequence analysis of 94 different clones identified TUG1, a noncoding RNA interacting with EZH2 identified by RIP assay (Khalil et al., 2009) and repressing cell cycle genes, as the most enriched RNA that interacted with methylated Pc2 (Figure S5A).”
A ceRNA hypothesis: the Rosetta stone of a hidden RNA language? (2011, background): “…epigenetic mechanisms, including X-inactive specific transcript (XIST), which is implicated in X chromosome inactivation (Brown et al., 1992), and the recently identified large intergenic noncoding (linc)-RNAs (Gong and Maquat, 2011; Guttman et al., 2009; Huarte et al., 2010; Khalil et al., 2009).”
Gene co-expression analysis for functional classification and gene–disease predictions (2017, background): “One of the major benefits of RNA-seq is that it quantifies the expression of the over 70 000 non-coding RNAs not usually measured with microarrays [1], including recently annotated lincRNAs, many of which are thought to have regulatory roles [41] and to play a role in disease [42, 43].”
Long Non-Coding RNA in the Pathogenesis of Cancers (2019, background): “Additionally, TUG1 can bind with PRC2 in the promotor region of Elav-like family member 1 (CELF1) to inhibit the expression of the genes involved in cell cycle [87].”
Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution (2015, background): “Validating our approach, 11 of the 12 lncRNA previously imaged by RNA FISH [6,19,21,25,49-56] showed patterns that were consistent with previous reports (Additional file 3).”
Long noncoding RNAs and the genetics of cancer (2013, background): “At least 38% of lncRNAs present in several human tissues bind to the polycomb repressive complex 2 or the chromatinmodifying proteins CoREST and SMCX (Khalil et al, 2009).”