A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa.

By A. Goodman, B. Kulasekara, A. Rietsch, D. Boyd, Roger S. Smith, S. Lory. Developmental Cell, 2004

636 citations recorded by the source corpus.

Subfields: Endocrinology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/693d2a976bbc80afcaf610a09ede1fb6869495ba

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. P. Watnick
2. E. Karatan

In Genetics

1. John D. Helmann
2. P. Kivistik
3. P. Watnick
4. E. Karatan

In Molecular Biology

1. John D. Helmann
2. P. Kivistik
3. P. Watnick
4. E. Karatan

Citations in the corpus

• ColR-ColS signalling system and transposition of Tn4652 in the adaptation of Pseudomonas putida (2010, background): “Although found in many gammaproteobacteria, this pathway has gained a lot of attention due to its role in the chronic persistent infection of P. aeruginosa (Goodman et al., 2004).”
• Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms (2008, background): “Additionally, the hybrid sensor kinases, LadS and RetS appear to work upstream of GacA to possibly control the switch to a biofilm lifestyle [34,35].”
• A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria (2010, methodology): “aeruginosa through the small RNA-binding protein RsmA (Brencic and Lory, 2009; Goodman et al., 2004; Ventre et al., 2006).”
• Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms (2009, background): “These traits are lost from isolates from patients with chronic infection (114).”
• The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa (2012, background): “aeruginosa retS mutant was unable to establish infection (78).”
• The Type III Secretion System of Pseudomonas aeruginosa: Infection by Injection (2009, background): “aeruginosa for acute infections by inducing T3SS genes and normal piliation but repressing genes that promote biofilm growth, whereas LadS acts in a reciprocal manner by downregulating type III secretion during chronic infection”
• Stimulus Perception in Bacterial Signal-Transducing Histidine Kinases (2006, background): “So far, only one of these HKs has been functionally investigated: RetS-dependent signal transduction is important for reciprocally regulating acute infection and chronic persistence in Pseudomonas aeruginosa and is required for the expression of the type III secretion system and other virulence fact”