The Type III Secretion System of Pseudomonas aeruginosa: Infection by Injection

By A. Hauser. Nature Reviews Microbiology, 2009

944 citations recorded by the source corpus.

The Gram-negative bacterium Pseudomonas aeruginosa uses a complex type III secretion apparatus to inject effector proteins into host cells. The configuration of this secretion machinery, the activities of the proteins that are injected by it and the consequences of this process for infection are now being elucidated. This Review summarizes our current knowledge of P. aeruginosa type III secretion, including the secretion and translocation machinery, the regulation of this machinery, and the associated chaperones and effector proteins. The features of this interesting secretion system have important implications for the pathogenesis of P. aeruginosa infections and for other type III secretion systems.

Subfields: Endocrinology, Genetics, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/82a84e5f9fd8ab76f59ac9a3e7f5866af283c5f0

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In Endocrinology

1. Robert E. W. Hancock
2. D. Reynolds
3. S. Levy
4. Marin Kollef
5. S. Gellatly

In Genetics

1. Andriy Kryshtafovych
2. Robert E. W. Hancock
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4. D. Reynolds
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4. Marin Kollef
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Citations in the corpus

• Pseudomonas genomes: diverse and adaptable. (2011, background): “The involvement of three overlapping QS systems (Whiteley et al., 1999; Girard & Bloemberg, 2008), a T3SS (Hauser, 2009), sigma factors (Potvin et al., 2008) and two-component regulatory systems in controlling virulence and resistance in P. aeruginosa (Gooderham & Hancock, 2009) suggests that…”
• The Epidemiology and Pathogenesis and Treatment of Pseudomonas aeruginosa Infections: An Update (2021, background): “aeruginosa isolates with PcrV have been associated with higher mortality, and clinical studies are ongoing to assess response to PcrV-specific antibodies [61, 68].”
• Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics (2022, background): “The function of T3SS is regulated by various regulators, including four main regulators genes (exsA, exsC, exsD, and exsE), which is involved in the transcription activation of the aforementioned classical effectors (exoS, exoT, exoU, and exoY).(72,113) ExoS is a 48.”
• Pseudomonas aeruginosa: new insights into pathogenesis and host defenses. (2013, background): “…may allow Pseudomonas to exploit breaches in the epithelial barrier by antagonizing wound healing during colonization and to promote cell injury directly (i.e. via ExoU) and indirectly (i.e. recruitment and activation of neutrophils) leading to the symptoms of bacterial pneumonia (Hauser, 2009).”
• Comparative Genomics of Plant-Associated Pseudomonas spp.: Insights into Diversity and Inheritance of Traits Involved in Multitrophic Interactions (2012, background): “aeruginosa effector with phospholipase activity that causes rapid death in eukaryotic cells [113], is present in all strains with T3SSs except for strain Q8r196.”
• RNA target highlights in CASP15: Evaluation of predicted models by structure providers (2023, background): “64 The acute and chronic virulence of P. aeruginosa could be regulated by types III and VI secretion systems, 65,66 biofilm formation, 67 and quorum sensing, a cell density-based intercellular communication network.”