Aurora‐A overexpression reveals tetraploidization as a major route to centrosome amplification in p53−/− cells

By P. Meraldi, R. Honda, Erich A.Nigg. EMBO Journal, 2002

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Human TPX2 is required for targeting Aurora-A kinase to the spindle (2002, methodology): “Production of recombinant proteins and antibodies Aurora-A WT and K162R cDNAs (Meraldi et al., 2002) were GST tagged and subcloned into pVL13GST93 (Amersham Biosciences).”
The cellular geography of Aurora kinases (2003, background): “Two recent studies indicate that overexpression of Aurora A is unlikely to trigger centrosome amplification directly, but instead leads to mitotic abnormalities that culminate in the failure of cytokinesis and the production of tetraploid cell”
Aurora-A — A guardian of poles (2005, background): “Overexpression of Aurora-A also leads to cytokinesis failure, resulting in formation of binucleated cell”
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy (2010, result): “This indicated that the elevated levels of PLK1 induced by E6AP or HPV E7 has a principal role in the induction of tetraploidy, thus confirming previous studies describing PLK1 overexpression phenotype”