The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis.

By E. Sauvage, F. Kerff, M. Terrak, J. Ayala, P. Charlier. FEMS Microbiology Reviews, 2008

1,327 citations recorded by the source corpus.

Subfields: Ecology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/68ce3998cbd2a92538c5635b874eb1043441321f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. D. Kahne
2. T. Silhavy
3. Jean van Heijenoort

In Molecular Biology

1. Jan Kok
2. D. van Sinderen
3. Robert A. Bonomo
4. M. Gobbetti
5. D. Kahne
6. C. Stanton
7. T. Silhavy
8. Sarah M. Drawz

Citations in the corpus

• Peptidoglycan Hydrolases of Escherichia coli (2011, background): “Penicillin-binding proteins (PBPs) are a family of bacterial acyl-serine transferases of common evolutionary origin specifically inhibited by the covalent binding of -lactam antibiotics to their active sites (77, 156, 229, 312).”
• Stress Physiology of Lactic Acid Bacteria (2016, background): “-Lactam antibiotics, such as penicillin and its analogs, block PG biosynthesis through inhibition of the activity of a group of penicillin-binding protein (PBP) transpeptidases that catalyze the polymerization of the glycan strand or the cross-linking between glycan chains (362, 363).”
• The bacterial cell envelope. (2010, background): “Transpeptidases that couple branched stem peptides are mechanistically similar to those that couple unbranched stem peptides; however, their substrate specificity is sufficiently different that they only recognize unbranched stem peptides, and some of them are resistant to beta lactams (Rohrer and B”
• Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery (2014, background): “Bacteria encode a variety of PBPs that participate in PG assembly (Sauvage et al., 2008).”
• Cytoplasmic steps of peptidoglycan biosynthesis. (2008, background): “The present review deals with the cytoplasmic steps of peptidoglycan synthesis; the subsequent steps are reviewed by Bouhss et al. (2008) and Sauvage et al. (2008) in this issue.”
• Three Decades of β-Lactamase Inhibitors (2010, background): “A pentapeptide is attached to each NAM unit, and the cross-linking of two D-alanine–D-alanine NAM pentapeptides is catalyzed by PBPs, which act as transpeptidases (142, 377).”
• Penicillin-binding proteins and beta-lactam resistance. (2008, background): “The penicillin-binding domains of PBPs are transpeptidases or carboxypeptidases involved in peptidoglycan metabolism (Goffin & Ghuysen, 2002; Sauvage et al., 2008).”