The proteostasis network and its decline in ageing
By M. Hipp, P. Kasturi, F. Hartl. Nature reviews. Molecular cell biology, 2019
1,284 citations recorded by the source corpus.
Subfields: Cell Biology, Materials Chemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/687a187ed03fe899f68278b46ff6e4811ebdba35
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In Molecular Biology
Citations in the corpus
- Benefits of Metformin in Attenuating the Hallmarks of Aging (2020, background): “Loss of proteostasis—A highly regulated network of > 2000 proteins comprising of molecular chaperones, proteolytic systems and regulators, is crucial to maintain a stable proteome or protein homeostasis (proteostasis) (Hipp et al. 2019).”
- Measuring biological age using omics data (2022, background): “Additionally, loss of proteostasis is a hallmark of ageing 4,100 , and other hallmarks of ageing, such as dysregulated nutrient sensing, altered intercellular communication and cellular senescence, also imply alterations in the proteome such as differential levels of insulin and peptide hormones,…”
- Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, background): “Proteostasis disruption triggers adaptive changes in the cell.(104) To cope with this situation, cells have developed multiple mechanisms to reduce misfolding and remove misfolded proteins.”