The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications.

By A. Carnero, C. Blanco-Aparicio, Oliver Renner, W. Link, J. Leal. Current Cancer Drug Targets, 2008

862 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/684d416005748af0a5d106ce83b5b4add9c8bf54

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In Molecular Biology

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Citations in the corpus

• PI3K/Akt: getting it right matters (2008, background): “Silencing of PTEN is frequently observed in primary tumors and cancer cell lines (for review, see Carnero et al., 2008; Maehama, 2007; Salmena et al., 2008).”
• PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism (2020, background): “In turn, H2O2 may inhibit PTEN phosphatase activity by redox modulation [97, 98].”
• Targeting PI3K/Akt signal transduction for cancer therapy (2021, background): “Moreover, the p85 subunit can transmit various cellular signals by laying a critical foundation for signal integration and the activation of downstream proteins.(10) Class I PI3Ks are divided into four catalytic isoforms, p110α, p110β, p110γ and p110δ, and they are encoded by PIK3CA, PIK3CB, PIK3CG ”