AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

By J. Oakhill, Rohan Steel, Zhi-ping Chen, J. Scott, Naomi X. Y. Ling, S. Tam, Bruce E. Kemp. Science, 2011

622 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013, background): “As such, AMPK functions as a sensor of the cellular adenylate energy charge (84, 85).”
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. (2011, background): “Interestingly, it has recently been reported that mechanisms 1 and 2 can be triggered by binding of ADP as well as AMP (Oakhill et al. 2011; Xiao et al. 2011), although mechanism 3 is only observed with AMP.”
The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis (2016, neutral): “For example, AMP-activated protein kinase (AMPK) integrates the relative ATP concentration against AMP and/or ADP concentrations for signaling (Oakhill et al., 2011; Xiao et al., 2011).”
Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks (2011, background): “While AMP binding to the -subunit allosterically enhances AMPK kinase activity and prevents the dephosphorylation of T172, ATP is known to counteract the activating properties of AMP (30).”