Defining trained immunity and its role in health and disease

By Mihai G. Netea, Jorge Domínguez-Andrés, L. Barreiro, T. Chavakis, M. Divangahi, Elaine Fuchs, L. Joosten, J. V. D. van der Meer, M. Mhlanga, W. Mulder and 7 more. Nature reviews. Immunology, 2020

2,167 citations recorded by the source corpus.

Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity. Here a group of leaders in the field define our current understanding of ‘trained immunity’, which refers to the memory-type responses that occur in the innate immune system. The authors discuss our current understanding of the key epigenetic and metabolic processes involved in trained immunity and consider its relevance in immune-mediated diseases and cancer.

Subfields: Genetics, Health, Immunology

View Paper: https://www.semanticscholar.org/paper/6832495cc25d4f5fbd329529aec3753c5da2c60d

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In Immunology

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Citations in the corpus

• Astrocyte crosstalk in CNS inflammation (2020, background): “Pioneering studies have extended the concept of memory to the innate immune response, to describe “trained” innate immunity associated to extensive epigenetic and metabolic remodeling (Netea et al., 2020).”