Effective population size and patterns of molecular evolution and variation

By B. Charlesworth. Nature reviews genetics, 2009

1,653 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/67f8b92e60bb34031a8bac7edb45bdd740d52436

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

Citations in the corpus

Linkage disequilibrium estimates of contemporary Ne using highly variable genetic markers: a largely untapped resource for applied conservation and evolution (2009, background): “Effective population size (Ne) is widely regarded as one of the most important parameters in both evolutionary biology (Charlesworth 2009) and conservation biology (Nunney and Elam 1994; Frankham 2005), but it is notoriously difficult to estimate in nature.”
Non-coding RNA: what is functional and what is junk? (2015, neutral): “For modern humans, the effective population size has been calculated to be 10,000 throughout most of its history, which is typical for mammals (Charlesworth, 2009).”
Conservation genetics of population bottlenecks: the role of chance, selection, and history (2010, background): “…traits and adaptive potential One of the major consequences of population bottlenecks relates to their genetic and phenotypic effects on quantitative traits (Lynch 1991; Whitlock and Fowler 1996; Lynch and Walsh 1998; Moorad and Wade 2005; Van Buskirk and Willi 2006; Charlesworth 2009).”
Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence (2011, background): “; other species — for example, those with different effective population sizes in which the relative effectiveness of natural selection and genetic drift diffe”
Estimation of census and effective population sizes: the increasing usefulness of DNA-based approaches (2010, background): “Finally, it is worth mentioning the difficulty in long-term Ne estimation (Schwartz et al. 1999; Wang 2005; Charlesworth 2009).”
NeEstimator v2: re‐implementation of software for the estimation of contemporary effective population size (Ne) from genetic data (2014, methodology): “We recorded the minimum and maximum estimates for each method, as well as the harmonic mean ^ N e and the coefﬁcient of variation in 1/ ^ N e , which is the drift signal these methods respond to (Wang 2001, 2009).”
Population Genomics of Parallel Adaptation in Threespine Stickleback using Sequenced RAD Tags (2010, neutral): “migration in spatially distributed populations [1–6].”
Biome stability in South America over the last 30 kyr: Inferences from long‐term vegetation dynamics and habitat modelling (2018, background): “And even species widespread today will still tend to show low effective population sizes (as measured with molecular markers) compared with species inhabiting historically more stable areas (Charlesworth, 2009).”
Delimiting Species Using Single-Locus Data and the Generalized Mixed Yule Coalescent Approach: A Revised Method and Evaluation on Simulated Data Sets (2013, background): “The range of population size covers the estimated effective population sizes of common eukaryotic species (Charlesworth 2009).”
Genetic variation in responses to a settlement cue and elevated temperature in the reef-building coral Acropora millepora (2009, background): “The importance of effective population size (Ne) for adaptation has been extensively studied (Charlesworth 2009), and the response to selection by natural populations is expected to vary in proportion to Ne.”