Functional optimization of gene clusters by combinatorial design and assembly

By M. Smanski, Swapnil P Bhatia, Dehua Zhao, Yongjin P. Park, L. Woodruff, G. Giannoukos, Dawn M. Ciulla, Michele A. Busby, Johnathan Calderon, R. Nicol and 3 more. Nature Biotechnology, 2014

342 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/67ec6f30ded8fe02ba187945a78a4c2b1b51d719

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Christopher A. Voigt

In Molecular Biology

1. D. G. Gibson
2. Wendell A. Lim
3. N. Assad-Garcia
4. Thomas J. Deerinck
5. John I. Glass
6. Roland A. Richter
7. Christopher A. Voigt
8. Alec A. K. Nielsen

Citations in the corpus

• Design and synthesis of a minimal bacterial genome (2016, background): “For example, a cell could be designed with added metabolic pathways (34), an altered genetic code (35), or dramatically al-”
• Genetic circuit design automation (2016, methodology): “A combinatorial design algorithm ( 83 ) is used to build a genetic construct that conforms to the constraints (fig.”
• Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors (2016, positive): “…and synthetic biology and describes rebuilding a complex program or system from the bottom up in a more modular and logical way that allows for a higher degree of control, predictability, and extensibility (the ability to extend the system to performmore complex functions) (Smanski et al., 2014).”