Design and synthesis of a minimal bacterial genome

By C. Hutchison, R. Chuang, V. Noskov, N. Assad-Garcia, Thomas J. Deerinck, Mark Ellisman, J. Gill, K. Kannan, B. Karas, Li Ma and 13 more. Science, 2016

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A global interaction network maps a wiring diagram of cellular function (2016, background): “Ultimately, broad mapping of both core and condition-specific genetic interactions promises to accelerate the field of synthetic biology, providing a rational understanding of the requirements for the design of minimal genomes (38).”
A scalable pipeline for designing reconfigurable organisms (2020, background): “Single-cell organisms have been modified by refactored genomes, but such methods are not yet scalable to rational control of multicellular shape or behavior (4).”
Deep Semantic Protein Representation for Annotation, Discovery, and Engineering (2018, background): “While genome annotation has evolved from a laborious manual process to a largely automated endeavor with a proliferation of sophisticated tools and pipelines, many proteins, including some essential for life 4 , still have no known function.”