Characteristics of SARS-CoV-2 and COVID-19
By Ben Hu, Hua Guo, P. Zhou, Zhènglì Shí. Nature Reviews Microbiology, 2020
4,449 citations recorded by the source corpus.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety. In this Review, we describe the basic virology of SARS-CoV-2, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses. We summarize current knowledge of clinical, epidemiological and pathological features of COVID-19, as well as recent progress in animal models and antiviral treatment approaches for SARS-CoV-2 infection. We also discuss the potential wildlife hosts and zoonotic origin of this emerging virus in detail. In this Review, Shi and colleagues summarize the exceptional amount of research that has characterized acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) since this virus has swept around the globe. They discuss what we know so far about the emergence and virology of SARS-CoV-2 and the pathogenesis and treatment of COVID-19.
Subfields: Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/679904bd007ec759714f30610db445bd43775cf2
Citations in the corpus
- Structural Analysis of the SARS-CoV-2 Omicron Variant Proteins (2021, background): “The AA mutations of K417N, N440K, Q493R, and Q498R could change the charge characteristics of amino acids (Figure 1(i)), which may influence the interactions between the RBD and ACE2.”
- Search and sequence analysis tools services from EMBL-EBI in 2022 (2022, neutral): “The COVID-19 pandemic caused by the severe acute respiratory syndrome cCoronavirus 2 (SARS-CoV-2) and the lockdown measures implemented by governments world-wide to contain it has caused unprecedented economic and societal disruption (1).”
- Adaptive immunity to SARS-CoV-2 and COVID-19 (2021, neutral): “Coronavirus disease 2019 (COVID-19), caused by the novel human pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Hu et al., 2020), is a serious disease that has resulted in widespread global morbidity and mortality.”