The role of iron in brain ageing and neurodegenerative disorders
By R. Ward, F. Zucca, Jeff H. Duyn, R. Crichton, L. Zecca. Lancet Neurology, 2014
1,566 citations recorded by the source corpus.
In the CNS, iron in several proteins is involved in many important processes such as oxygen transportation, oxidative phosphorylation, myelin production, and the synthesis and metabolism of neurotransmitters. Abnormal iron homoeostasis can induce cellular damage through hydroxyl radical production, which can cause the oxidation and modification of lipids, proteins, carbohydrates, and DNA. During ageing, different iron complexes accumulate in brain regions associated with motor and cognitive impairment. In various neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, changes in iron homoeostasis result in altered cellular iron distribution and accumulation. MRI can often identify these changes, thus providing a potential diagnostic biomarker of neurodegenerative diseases. An important avenue to reduce iron accumulation is the use of iron chelators that are able to cross the blood–brain barrier, penetrate cells, and reduce excessive iron accumulation, thereby affording neuroprotection.
Subfields: Endocrinology, Diabetes and Metabolism, Hematology, Neurology
View Paper: https://www.semanticscholar.org/paper/678eb5fafcfe5243b063a7040e2aac9a04dee675
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- A. Zaheer
- Daniyal Saeed
- Prashant Natteru
- S. Iyer
- D. Kempuraj
- G. P. Selvakumar
- Smita A. Zaheer
- R. Thangavel
Citations in the corpus
- Neuroinflammation Induces Neurodegeneration (2016, background): “Iron ferritin concentration increases in microglia and induces proinflammatory dystrophic microglia phenotype in the elderly and thus contribute to the pathogenesis of neurodegenerative diseases [27,29].”
- The Tumor Suppressor Protein p53 and the Ferroptosis Network (2018, neutral): “Excess iron can be a risk for carcinogenesis and neurodegenerative diseases [79,80].”