A dynamic COVID-19 immune signature includes associations with poor prognosis

By Adam G. Laing, A. Lorenc, Irene del Molino del Barrio, Abhishek Das, Matthew Fish, L. Monin, M. Muñoz-Ruiz, Duncan R. McKenzie, T. Hayday, Isaac Francos-Quijorna and 40 more. Nature Medicine, 2020

860 citations recorded by the source corpus.

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/6776caf2baf21a173569ada74db3192f21d948c1

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In Infectious Diseases

1. Alessandro Sette
2. Shane Crotty
3. Ralph S. Baric

In Neurology

1. Shane Crotty
2. Ralph S. Baric

Citations in the corpus

• Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant (2021, background): “However enhanced B.1.1.7 Orf9b sgRNA synthesis is likely mediated by changes in N (28,880 GAT>CAT, D3L) that enhance complementarity between the Orf9b TRS and TRS-L surrounding sequences 40 .”
• Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes (2020, neutral): “One of the hallmarks of TNF-a and IFN-g shock or severe COVID-19 is lymphopenia (Laing et al., 2020).”
• Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity (2020, positive): “…(IP-10), IL-8, and IL-6 were elevated in acute COVID-19 (p < 0.0001, p < 0.05, p < 0.001; Figures S5A–S5C) and correlated with disease severity (Figure 5A), consistent with large cohort studies of plasma cytokines (Chen et al., 2020; Laing et al., 2020; Mathew et al., 2020; Yang et al., 2020).”