Causes and Consequences of Replication Stress

By M. Zeman, Karlene A. Cimprich. Nature Cell Biology, 2013

1,890 citations recorded by the source corpus.

Replication stress is a complex phenomenon that has serious implications for genome stability, cell survival and human disease. Generation of aberrant replication fork structures containing single-stranded DNA activates the replication stress response, primarily mediated by the kinase ATR (ATM- and Rad3-related). Along with its downstream effectors, ATR stabilizes and helps to restart stalled replication forks, avoiding the generation of DNA damage and genome instability. Understanding this response may be key to diagnosing and treating human diseases caused by defective responses to replication stress.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/674f27a54353172213dbd5ea182d999c8eafeda6

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Citations in the corpus

• BRD4 and Cancer: going beyond transcriptional regulation (2018, background): “Replication stress, induced among the others by oncogene increased transcription or DNA replication, is a complex phenomenon which has serious implications for genome stability [64].”
• Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas (2018, neutral): “For example, HR defects are common in many cancer types and may compromise successful DNA replication and genome stability (Macheret and Halazonetis, 2015; Zeman and Cimprich, 2014).”
• ROS and the DNA damage response in cancer (2018, background): “physical obstacles to the replication fork [29].”