Fc receptor but not complement binding is important in antibody protection against HIV

By A. Hessell, Lars Hangartner, Meredith Hunter, C. Havenith, F. Beurskens, J. Bakker, Caroline M. S. Lanigan, G. Landucci, D. Forthal, P. Parren and 2 more. Nature, 2007

934 citations recorded by the source corpus.

Subfields: Immunology, Radiology, Nuclear Medicine and Imaging, Virology

View Paper: https://www.semanticscholar.org/paper/673ed6592d9a2cdd341fcd1e9371e2f595a85af8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Rafi Ahmed
2. F. Sallusto
3. A. Lanzavecchia
4. K. Araki
5. Bali Pulendran
6. E. Wherry
7. S. Kaech
8. V. Schirrmacher

In Radiology, Nuclear Medicine and Imaging

1. F. Sallusto
2. Rafi Ahmed
3. K. Araki
4. A. Lanzavecchia

In Virology

1. F. Sallusto
2. Rafi Ahmed
3. Beatrice H. Hahn
4. K. Araki
5. A. Lanzavecchia
6. John C. Mingers
7. Leroy White

Citations in the corpus

• Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection (2016, neutral): “This panel also contained Fc mutant versions of mAbs that do not bind to FcγR and complement (LALA mutants) (21, 32).”
• From Vaccines to Memory and Back (2010, positive): “One should consider that in vitro neutralization assays do not fully reflect the in vivo usefulness of antibodies since this may critically depend on effector mechanisms such as complement-or Fc receptor-mediated killing (Hessell et al., 2007; Mozdzanowska et al., 2006).”
• Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia (2008, background): “tion (ADCVI) activity (29) also did not appear within the first”