Structure of the Quaternary Complex of Interleukin-2 with Its α, ß, and γc Receptors

By Xinquan Wang, M. Rickert, K. Garcia. Science, 2005

358 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/66f6dff4db9303e58cb5f63c1ef58dea4dfbaf47

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In Immunology

1. Scott T R Walsh
2. J. A. Dohm
3. C. McElroy

Citations in the corpus

• Structural and Biophysical Studies of the Human IL-7/IL-7Rα Complex (2009, methodology): “If the D2 domain interactions observed in both the IL-2 and IL-4 structures are conserved in the IL-7 complex, then gc must adopt a different conformation from the ones observed in the IL-2 and IL-4 structures (Laporte et al., 2008; Wang et al., 2005).”
• Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, neutral): “The crystal structure of IL-2 bound to the IL-2R provides molecular support for a model where IL-2 drives assembly of the highaffinity trimeric receptor (Stauber et al., 2006; Wang et al., 2005).”