Mechanisms of hepatotoxicity.

By H. Jaeschke, G. Gores, A. Cederbaum, J. Hinson, D. Pessayre, J. Lemasters. Toxicological Sciences, 2002

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High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening (2006, background): “Despite the poor predictivity, there is reasonable understanding of the general pathophysiological mechanism of most drug-induced hepatotoxicities (Boelsterli 2003a, b; Jaeschke et al. 2002; Lee 2003; Xu et al. 2004).”
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes? (2005, background): “Perturbations in mitochondrial membrane permeability may increase cellular free radicals that cause mitochondrial DNA damage, impair mitochondrial function, and activate pro-apoptosis cascades [53,54].”
Three or more routes for leukocyte migration into the central nervous system (2003, background): “However, neurotoxin injections in the CNS, which induce marked neuronal necrosis, fail to elicit a typical leukocyte respons”
Free radicals, antioxidants and functional foods: Impact on human health (2010, background): “[73] However, like ascorbate, uric acid can also mediate the production of active oxygen species.”