Metallo-β-Lactamases: the Quiet before the Storm?

By T. Walsh, M. Toleman, L. Poirel, P. Nordmann. Clinical Microbiology Reviews, 2005

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Global Spread of Carbapenemase-producing Enterobacteriaceae (2011, methodology): “Endemicity of VIM- and IMP-type enzymes has been reported in Greece, Taiwan, and Japan (2,12), although outbreaks and single reports of VIM and IMP producers have been reported in many other countries (Figure 3).”
Carbapenem resistance: overview of the problem and future perspectives (2016, background): “Both IMP- and VIM-type enzymes have successfully spread to all continents since then [Walsh et al. 2005].”
Characterization of a New Metallo-β-Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India (2009, background): “coli TOP10 and J53 compared with those for strains with the other cloned MBL genes (31, 41).”
Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. (2012, background): “[5] published a review article entitled ‘Metallo-b-lactamases: the quiet before the storm?’ Although they specifically reviewed the biochemical and genetic characterization of metallo-b-lactamases (MBLs), they also pointed out that the continued spread of carbapenemases worldwide would result in a c”