Biochemical and cellular properties of insulin receptor signalling
By R. Haeusler, T. McGraw, D. Accili. Nature reviews. Molecular cell biology, 2017
623 citations recorded by the source corpus.
The mechanism of insulin action is a central theme in biology and medicine. In addition to the rather rare condition of insulin deficiency caused by autoimmune destruction of pancreatic β-cells, genetic and acquired abnormalities of insulin action underlie the far more common conditions of type 2 diabetes, obesity and insulin resistance. The latter predisposes to diseases ranging from hypertension to Alzheimer disease and cancer. Hence, understanding the biochemical and cellular properties of insulin receptor signalling is arguably a priority in biomedical research. In the past decade, major progress has led to the delineation of mechanisms of glucose transport, lipid synthesis, storage and mobilization. In addition to direct effects of insulin on signalling kinases and metabolic enzymes, the discovery of mechanisms of insulin-regulated gene transcription has led to a reassessment of the general principles of insulin action. These advances will accelerate the discovery of new treatment modalities for diabetes.
Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/6615a5f5367b25880a96cf3a4f40f49aad439544
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Citations in the corpus
- Diabetic vascular diseases: molecular mechanisms and therapeutic strategies (2023, background): “The insulin receptor signaling system plays an important role in maintaining normal brain and cognitive functions(84) by regulating GLP-1 receptors,(84,85) insulin receptor substrate (IRS) receptors.(86,87) In other tissues, insulin activates the glucose transporter (GLUT) family of glucose transpor”
- Trends in insulin resistance: insights into mechanisms and therapeutic strategy (2022, background): “Insulin binds the insulin receptor (INSR) on the plasma membrane of target cells, leading to the recruitment/phosphorylation of downstream proteins, that primarily including insulin receptor substrate (IRS), PI3-kinase(PI3K), and AKT isoforms, that are largely conserved among insulin target tissues ”