Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin
By T. Hirota, Jesse J. Lipp, B. Toh, J. Peters. Nature, 2005
707 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/660b2b0ec029b03b28d3848b4f898dc8cd31e472
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Citations in the corpus
- Histone Modifications and Cancer. (2016, background): “H3 serine 10 phosphorylation adjacent to the trimethylated H3 (H3K9me3S10ph) by Aurora B causes dissociation of HP1 from heterochromatin during M phase and allows for mitotic progression (Fischle et al. 2005; Hirota et al. 2005).”
- Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1. (2011, methodology): “[5] Hirota T, Lipp JJ, Toh BH, and Peters JM (2005).”
- Roles of Aurora Kinases in Mitosis and Tumorigenesis (2007, background): “routine disassociation of HP1 from heterochromatin (57, 58), but the biological effect of HP1 release in mitosis is still”
- Non-commercial Research and Educational Use including without Limitation Use in Instruction at Your Institution, Sending It to Specific Colleagues That You Know, and Providing a Copy to Your Institution's Administrator. All Other Uses, Reproduction and Distribution, including without Limitation Comm (2005, neutral): “(1) in which all the dipole–dipole couplings and chemical shielding parameters are varied.”
- Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division (2014, background): “Most HP1 protein typically dissociates from chromosomes during mitosis in an H3 serine 10 phosphorylated manner (Fischle et al., 2005; Hirota et al., 2005).”
- The interplay of histone modifications – writers that read (2015, positive): “Interestingly at mitosis, H3 is phosophorylated by the kinase Aurora B at H3S10, and this modification next to the H3K9me3 mark causes HP1 to be displaced from the pericentric heterochromatin during this phase of the cell cycle [120].”
- Regulation of nucleosome dynamics by histone modifications (2013, positive): “Binding of HP1 chromo-domains to peptides harboring H3K9me3 is severely impaired by H3S10 phosphorylation (H3S10p), and the co-occurrence of H3K9me3 and H3S10p coincides with the release of HP1 from mitotic chromatin 60,61 .”
- The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes (2008, background): “Phosphorylation of this residue triggers dissociation of HP1 even if lysine 9 is methylated (Hirota et al., 2005).”